PTEN and neoplasm: CNV analysis from these studies have also validated some of the initial findings from aCGH studies, showing recurrent losses of chromosomal regions involving key tumor suppressor genes such as PTEN (10q), RB1 (13q), CDH1 (16q), and TP53 (17p), while the most frequent copy number gains involved chromosome regions 17p11.2 (MYOCD) and 15q25-26 (IGF1R) [20,22].