This differential has been observed with many other tumor cell types in the past: although NEO212 is always more potent than TMZ in MGMT-positive cells, the inclusion of O6BG nonetheless has consistently been found to moderately enhance its cytotoxic impact further, confirming that the methylation of O6-guanine plays a role in NEO212’s anticancer impact [39,40,43]. The gene discussed is MGMT; the disease is neoplasm.