PIK3CA and cancer: The top mutated cancer genes in this cohort were TP53 (n = 167), KRAS (n = 127), EGFR (n = 65), STK11 (n = 32), ERBB2 (HER2) (n = 26), MET (n = 24), PIK3CA alterations (n = 19), etc. (Table 2).