Muller L. et al. showed that the signals produced by exosomes isolated from HNSCC (head and neck squamous cell carcinoma) modulate gene expression in human Tregs, and the highest transcriptional activity was observed in immunoregulatory genes such as PD-L1, PD-1, CD40L, CD25, and ZAP-70 [113]. This evidence concerns the gene CD40LG and head and neck squamous cell carcinoma.