Jing Cai et al. treated ovarian cancer cells with exosomes derived from the peritoneal fluid (ascites-derived exosomes: ADEs) of ovarian cancer patients and observed a morphological and immunohistochemical change from an epithelioid to a mesenchymal phenotype (elongated, spindle-shaped shape, decreased E-cadherin expression, increased N-cadherin, and vimentin expression) [38]. This evidence concerns the gene CDH1 and ovarian carcinoma.