Chen G et al. studied the communication of exosomes with the immune environment and found that exosomes derived from the human melanoma cell line MEL624 were characterized by an increased expression of PD-L1, directly inhibiting the antitumor function of CD8 T cells (proliferation and cytotoxicity), as evidenced by a reduced expression of Ki-67 and granzyme B (GzmB) and an inhibited production of IFN-γ, IL-2, and TNF-α [110]. This evidence concerns the gene GZMB and melanoma.