γδ-T-exosomes directly induce apoptosis in NPC cells, and, more importantly, CSCs via Fas/FasL and TRAIL/DR5 interactions. They also facilitate T cell migration into TME by upregulating their expression of CCR5, further limiting the expansion of NPC cells. When combined with irradiation, γδ-T-exosomes also concentrate more in the TME, showing a synergistic effect. This evidence concerns the gene TNFRSF10B and nasopharyngeal carcinoma.