For example, in both SMARCB1-null rhabdoid tumor cells and ARID1A-null colorectal cancer cells, loss of their respective SWI/SNF subunits is associated with a specific collapse of enhancers linked to differentiation and development, while those enhancers driving stemness and renewal remain open and active [11,15,16]. The gene discussed is SMARCB1; the disease is neoplasm.