At least as it relates to rhabdoid tumors, AP-1 involvement in pro-tumorigenic processes is a novel concept and could be related to the ability of AP-1 to recruit SWI/SNF to enhancers, albeit the enhancers in this case are not being used for the completion of differentiation and development as is the accepted paradigm [23,37]. The gene discussed is JUNB; the disease is rhabdoid tumor.