GAPDH and neoplasm: (2) Catalytically inactive glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was found to bind to damaged mitochondria and incorporate these mitochondria directly into lysosomes, exhibiting a characteristic immunohistochemical GAPDH staining pattern in Warthin’s tumor cells, suggesting either whole cell progressive loss of cytoplasmic GAPDH (Figure 3), likely due to loss or nuclear shift of the protein [18].