The role of CXCL12/CXCR4–CXCR7 is well-documented, with abnormal expression levels of either CXCL12 or CXCR4/CXCR7 correlating with clinicopathological features of HCC [238,239,240,241]. This evidence concerns the gene CXCL12 and hepatocellular carcinoma.