Other risk factors for HCC onset are non-viral chronic hepatitis (e.g., alpha-1-antitrypsin deficiency, hereditary hemochromatosis, and glycogen storage disease); alcohol-abuse-related steatosis; nonalcoholic steatohepatitis (NASH); environmental exposure to aflatoxin B1; and cigarette smoking [3]. The gene discussed is SERPINA1; the disease is metabolic dysfunction-associated steatohepatitis.