For instance, CXCL9–CXCL10/CXCR3, which has prognostic value in HCC patients [248], along with CXCL1–CXCL2/CXCR2, for which upregulation is an indicator of increased risk for HCC development [249]. This evidence concerns the gene CXCL1 and hepatocellular carcinoma.