As AML often over expresses the anti-apoptotic BCL-2 family proteins, BCL-2, BCL-xL, and MCL-1, we generated sublines of CD33+ EOL-1, ML-1, and MV4;11 cells overexpressing BCL-2, BCL-xL, or MCL-1. The gene discussed is MCL1; the disease is acute myeloid leukemia.