ABCG2 and acute myeloid leukemia: Because drug resistance due to ABC transporter proteins such as P-glycoprotein and BCRP is common in AML [45], we generated sublines of three human AML cell lines (EOL-1, MOLM-13, and MV4;11) to overexpress either P-glycoprotein or BCRP and studied their effect on CC-96191-induced cytotoxicity.