In these PBMC co-cultures, NK cell-activation correlated with the potency of target cell cytolysis, with CC-96191 being substantially more potent than lintuzumab and, at higher doses, reaching the same maximal cytolytic effect as was obtained with a CD33/CD3 BsAb in causing AML cell death (Figure 5C). Here, CD33 is linked to acute myeloid leukemia.