CD33 and acute myeloid leukemia: Likewise, with KHYG-1CD16a cells, CC-96191 caused substantially greater cytolysis of CD33+ EOL-1, ML-1, or TF-1 cells than either the CC-96191ΔNKG2D or the CC-96191ΔCD33TriNKET (Figure 2D), again demonstrating NKG2D and CD33 co-engagement is required for maximal cytolytic activity of CC-96191 against CD33+ human AML cell lines.