GL ≤ 6 carcinomas in the very-low-risk group (PSA ≤ 10 ng/mL and tumor in ≤2 biopsies with an infiltration grade > 50%) could still be actively monitored, while interventional therapies (prostatectomy, radiation therapy) were recommended for low-, intermediate- and high-risk tumors [23,26,27]. The gene discussed is KLK3; the disease is carcinoma.