This study aims to evaluate the morphological and functional features of breast cancer on CEM examination (shape, margins, dimensions and enhancement of the target lesion, according to ACR BI-RADS Mammography V edition) [26,27,28,29] that can predict the prognostic factors such as the histological type, histological grade, estrogen receptor (ER), progesterone receptor (PgR), Ki67, human epidermal growth factor receptor 2 (HER2) status and node invasion and, thus, the outcome of the disease. This evidence concerns the gene ERBB2 and breast cancer.