Further, ChIP assays in BGC-823 and MGC-803 cells showed that EZH2 and H3K27me3 are enriched at promoters of various tumor suppressor genes (CDH1, EAF2, ADRB2, RUNX3, and RAP1GAP) in a SNHG22-dependent manner, since SNHG22 loss-of-function reduced the levels of EZH2 and H3K27me3 and increased the expression of all tumor suppressor genes analyzed, which in turn also inhibited the proliferation and invasion ability of gastric cancer cells. Here, SNHG22 is linked to gastric cancer.