MALAT1 and osteosarcoma: The degradation of MALAT1 mediated by miR-9 was shown in osteosarcoma cells MG-63 that were treated with 17β-estradiol, which increased miR-9 levels, degraded MALAT1, and reduced several cancer hallmarks, including cell proliferation, colony formation, migration, and invasion (Figure 2, right) [57].