Although many of the differentially expressed genes in each cell line were distinct, we identified a 132-gene YAP/TAZ signature consisting of genes that were upregulated (80 genes) or downregulated (52 genes) in A375-YAP2SA cells and at least two of the other metastatic melanoma cell lines (Figure 2A,C and Table S3). This evidence concerns the gene WWTR1 and metastatic melanoma.