YAP1 and melanoma: Here, we show that the expression of mutant forms of YAP that are insensitive to LATS-mediated cytoplasmic sequestration (YAPS127A) or to both LATS-mediated cytoplasmic sequestration and proteasomal degradation (YAP2SA) in A375 human melanoma cells increased TEAD transcriptional activity and enhanced metastatic colonization of the lung (Figure 1A–D).