Although increases in YAP1 or WWTR1 (TAZ) mRNA expression in a tumor could result in increased protein expression and thus elevated YAP/TAZ activity, most of the regulation of YAP and TAZ occurs at the post-translational level, so YAP1 or WWTR1 mRNA expression is likely not the best readout for YAP/TAZ activity. This evidence concerns the gene WWTR1 and neoplasm.