MSH6 and cancer: MLH1 and MSH2 mutations also result in an earlier age of cancer diagnosis compared to MSH6 and PMS2 mutations, as the diagnosis of CRC occurs at around 27–42 years of age for MSH2/MLH1 mutations [34,35], whereas for MSH6 and PMS2 mutations, CRC occurs at 54–63 and 47–66 years of age, respectively [9,36].