In addition, the present study revealed that upregulated metabolites were enriched in the metabolism of xenobiotics by cytochrome P450 and involved bile secretion in the regulation of the immune pathway [48], and bile has been reported to protect organisms from intestinal infections through the secretion of immunoglobulin A (IgA) and inflammatory cytokines and the stimulation of the intrinsic immune system of the intestinal tract [49]. This evidence concerns the gene CD79A and digestive system infectious disorder.