The expression pattern for E-cadherin and β-catenin, as determined using immunohistochemistry, was predominantly membranous and weakly cytoplasmic for E-cadherin and predominantly membranous and weakly to moderate cytoplasmic for β-catenin, in both prostatic adenocarcinoma and the adjacent nonneoplastic prostatic tissue. The gene discussed is CDH1; the disease is prostate adenocarcinoma.