In our study, we analyzed the immunoexpression of E-cadherin and β-catenin cell adhesion proteins in periacinar retraction clefting in prostatic adenocarcinoma and in the adjacent nonneoplastic prostatic tissue and we correlated it with GSC, Grade Group, preoperative sPSA, surgical margin status, and the TNM staging in prostatic adenocarcinoma. Here, CDH1 is linked to prostate adenocarcinoma.