Since the available data on these lesions come from biopsy sampling [6,7,8], with the consequent limitations due to tissue dissociation, superficiality of sampling, and inappropriate section plane, we planned to analyze mucosal hyper mucinous proliferations, defined as raised lesions with continuous rows of enterocytes with high mucin content in the epithelial lining, in a cohort of ileocolonic surgical resections for IBD, where a good orientation of the tissue is more easily obtained. Here, MUC5AC is linked to inflammatory bowel disease.