BRCA1 and cholangiocarcinoma: There are several mutations that are associated with both fluke and non-fluke-related CCA, for example APC, BRAF, BRCA1 and 2, CDKN1B, CTNNB1, ELF3, KRAS, P4HTM, RASA1, RB1, STK11, TGFBR2, ACVR2A, ARID2, NCOR1, NRAS, PBRM1, PIK3R1, RNF43, SF3B1 and ASXL1.