Another recent research group from Boston Children’s Hospital built an ML model for the prediction of impending CLABSIs in 7468 hospitalized cardiac patients and indicated that the model could predict 25% of positive blood cultures with the major predictors being prior history of infection, elevated maximum heart rate, elevated maximum temperature, elevated C-reactive protein, exposure to parenteral nutrition and use of alteplase for central venous catheter (CVC) clearance [139]. The gene discussed is CRP; the disease is infection.