Another original aspect of our study is to determine the increased level of CD94+ and CD38+CD73+ NK cells in the blood in CVHC patients with severe liver fibrosis, with both 1 and 3 genotypes of HCV, which determines the low functional activity of NK cells (due to a decrease in synthesis of perforins and granzymes). This evidence concerns the gene KLRD1 and Hepatic fibrosis.