Doing so will bridge key findings on T cell immunity in non-HPV-related cSCC models, where tumour-specific cytotoxic T cells (primarily Th1 and CD8+ T cells) inhibit UVB and/or chemical carcinogenesis, while tumour-infiltrating regulatory T cells (Tregs) likely suppress anti-tumour immunity [37]. The gene discussed is CD8A; the disease is skin squamous cell carcinoma.