In contrast, orthodenticle homobox1 (OTX1) acts as a transcription factor and has been shown to function as a potential oncogene, with its overexpression observed in various cancers, including breast cancer, colorectal cancer, hepatocellular carcinoma, and bladder cancer [46,49,50,51,52]. The gene discussed is OTX1; the disease is urinary bladder carcinoma.