ACE and hypertensive disorder: As shown in Figure 3, compared with the WKY group, the contents of ACE and Ang II in the sera of the SHRs in the KB group were significantly increased (p < 0.001, p < 0.001), while the contents of ACE 2 and Ang 1-7 were significantly decreased (p < 0.05, p < 0.01), which was in agreement with the results reported by Sun et al., who found that hypertension can affect the contents of substances related to ACE regulation in the rat sera [30].