Therefore, the combination of a GLP-1RA and an FGF-21 analog in the same molecule seems to be an appealing approach; however, further studies in different animal models are required to achieve more secure results and, importantly, to elucidate the effect of GLP-1RA/FGF-21 analog on hepatic fibrosis. The gene discussed is FGF21; the disease is Hepatic fibrosis.