RORA and fatty liver disease: Yu et al. employed a HFD-induced NAFLD mouse model with hepatocyte-specific ablation of the retinoic acid receptor-related orphan receptor α (RORα) (RORα-LKO) to demonstrate that liraglutide alleviated hepatic steatosis via RORα-dependent autophagy activation, thus highlighting another mechanism of autophagy activation by GLP-1RAs [28].