showed that the beneficial effects of liraglutide on the liver were achieved through stimulating the Sestrin2-mediated nuclear factor-erythroid 2-related factor-2 (Nrf2)/heme oxygenase-1 (HO-1) pathway, suggesting another potential mechanism via which liraglutide ameliorates NAFLD through enhancing the antioxidative potential of the liver cells [20]. The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatotic liver disease.