Results from the TODAY study, a multicentered randomized clinical trial combining lifestyle and drug treatment choices in 699 obese young patients (aged 10–17 years) with T2DM reported that metformin monotherapy resulted in durable glycemic control (HbA1c < 8% without requirement of insulin therapy) in only 50% of the participants, metformin plus rosiglitazone had superior results to metformin monotherapy and metformin combined to lifestyle intervention program had no difference to metformin alone. The gene discussed is INS; the disease is type 2 diabetes mellitus.