INS and type 2 diabetes mellitus: Another randomized clinical trial, The Restoring Insulin Secretion (RISE) Pediatric Medication Study, including 91 overweight or obese patients (aged 10–19 years) with IGT or newly diagnosed T2DM (<6 months), compared two different treatment approaches, 3 months of insulin glargine followed by 9 months of metformin or 12 months metformin alone, in order to evaluate the β-cell function during and after treatment.