PDX1 and type 2 diabetes mellitus: Regarding the contribution of epigenetic factors, rodent data indicate that depletion of m6 mRNA methylation leads to islet phenotype of early-onset T2DM, via inducing cell-cycle arrest and impairing insulin secretion via inhibition of protein kinase B (AKT) phosphorylation and pancreatic duodenal homeobox 1 (PDX1) protein levels [38].