Our research applied LPS-induced ALI and PEBP4 KO models to highly demonstrated that PEBP4 deficiency can aggravate ALI and AFC, and this function may be partly mediated specifically by PI3K/AKT signaling pathway (Fig. 6), which will provide a foundation for PEBP4 as the target for ALI. The gene discussed is AKT1; the disease is acute respiratory distress syndrome.