As shown in this study, the expression of ENaC-α and ENaC-γ, and Na, K-ATPase in ALI with PEBP4 KO partially reversed by 740YP or SC79 as well, concomitant with further increase of both p-PI3K and p-AKT levels (Fig. 5). Here, SCNN1G is linked to acute respiratory distress syndrome.