In this study, we successfully established an LPS-induced ALI mouse model and found that the expression of PEBP4, a secreted protein with a variety of biological functions [8, 9], in lung tissue was down-regulated after LPS treatment (Fig. 1A), suggesting that PEBP4 might be involved in the development of ALI. The gene discussed is PEBP4; the disease is acute respiratory distress syndrome.