Although the role of RIC3 in α7-signaling dysfunction has not been explored, α7 nAChR expression is reduced in the brain of schizophrenic patients [5, 57] and the levels of RIC3 mRNA in the brains of schizophrenia patients, postmortem, are greater than in typical brains [26]. The gene discussed is RIC3; the disease is schizophrenia.