To identify genetic modulators for tau pathology, genome-wide association studies (GWAS) have been conducted and a few potential genetic risk factors were found in the tauopathy frontotemporal dementia [9, 44, 73, 86], including ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 1 protein (ASAP1). The gene discussed is MAPT; the disease is tauopathy.