MAPT and supranuclear palsy, progressive, 1: When we co-treated the neurons with MSUT2 ASOs and pathogenic protein seeds from AD, CBD, or PSP brains, or mSyn-pffs, we found that tau inclusions, but not α-syn aggregates, were reduced in the ASO-treated neurons compared to PBS- or scrambled sequence control (SCR)-treated neurons (Fig. 4a, b).