In the patients with small-vessel PSV, the occurrence of CVE was associated with older median age (66.0 [IQR 8.0] vs 59.0 [23.0], p = 0.04), higher median CRP (115.0 [IQR 137.0] vs 55.0 [IQR 113.28] mg/L, p = 0.02), higher median VDI (3.0 [IQR 3.0] vs 2.0 [IQR 2.0], p < 0.001), hypertension (45.2% vs 26.1%, p = 0.005), Previous CVE (11.9% vs 1.7%, p < 0.001), and malignancy (14.3% vs 5.4%, p = 0.03). The gene discussed is CRP; the disease is Hypertension.