Of note, the Transcription Factor (TF) TFAP2C was identified among the top regulons based on the AUCell score in chemoresistant cells and not present in chemosensitive cells (Fig. 2c, d) and has previously been implicated in EMT signalling and chemoresistance in lung adenocarcinoma, but not yet in TNBC30,31. The gene discussed is TF; the disease is lung adenocarcinoma.