It is widely believed that depression exerts its influence on female reproduction through the hypothalamic–pituitary–adrenal (HPA) axis and the hypothalamic-pituitary-ovarian (HPO) axis58–61.Corticotropin-releasing hormone (CRH), originating from the hypothalamus, is implicated in various reproductive processes, including follicular development, ovulation, and luteolysis in the ovarian CRH62,63. Here, CRH is linked to depressive disorder.