It is widely believed that depression exerts its influence on female reproduction through the hypothalamic–pituitary–adrenal (HPA) axis and the hypothalamic-pituitary-ovarian (HPO) axis58–61.Corticotropin-releasing hormone (CRH), originating from the hypothalamus, is implicated in various reproductive processes, including follicular development, ovulation, and luteolysis in the ovarian CRH62,63. This evidence concerns the gene CRH and major depressive disorder.