‘Dementia’ observations were significantly lower in PSP cases than in other FTD subtypes, suggesting that this FTD subtype is less affected by dementia, whereas ‘compulsive behavior’ was consistently higher in FTD-TAR DNA-binding protein (TDP)-B, FTD-TDP-C compared with many other FTD subtypes (Extended Data Fig. 4b). This evidence concerns the gene TARDBP and frontotemporal dementia.