UBQLN2-A282V, UBQLN2-M446R, UBQLN2-P497S, UBQLN2-P497H, UBQLN2-P506T were chosen to include mutations both within the PXX domain, where ALS/FTD mutations are most commonly located, as well as outside of the PXX domain. This evidence concerns the gene UBQLN2 and amyotrophic lateral sclerosis.