MAPT and Alzheimer disease: Currently, the detection of conventional AD biomarkers of amyloid-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta $$\end{document}β deposition and tau pathology require expensive or invasive diagnostic tools, such as Positron Emission Tomography (PET), Magnetic Resonance Imaging (MRI), and cerebrospinal fluid (CSF) sampling6,7.