These results were accordant with that G1 was enriched in ER+ patients while G2 was enriched in HER2+ /TNBC patients (Supplementary Fig. 4, b), supporting the report that HER2+ breast cancers may originate from luminal progenitors and mature luminal cells, while luminal-A/B breast cancers likely originate from mature luminal cells29. This evidence concerns the gene ESR1 and breast cancer.