Module 7 in PC (Fig. 3H, Supplementary File 5), which was significantly enriched in upregulated DEG, included Toll-like response genes MEF2A, PPP2CB, MEF2C, RIPK2 and IRAK2. These analyses together thus provide evidence for increased apoptosis of FB and PC in AD accompanied in association with innate immune activation of EC. The gene discussed is RIPK2; the disease is Alzheimer disease.