Genes differentially expressed in microvascular cells with AD defined transcriptional signatures for dysfunctional angiogenesis with upregulated expression of genes for regulators of angiogenesis such HIF1A, ANGPT2 and FGF2 together with downregulation of genes for effectors of angiogenic and trophic signalling including VEGFA-VEGFR2. Here, ANGPT2 is linked to Alzheimer disease.