SOX9 and colorectal carcinoma: To understand the functional relationship between SMARCB1 and SOX9, we started by measuring SOX9 expression levels in SMARCB1 KD lines, which showed a consistent ~50% reduction in SOX9 mRNA transcripts in HT29, HT115, and PDO CRC models (Fig. 4f, h and Supplementary Fig. 4f).