RSPO1 and Familial adenomatous polyposis: SMARCB1 KD reduced SOX9 and induced KRT20 mRNA expression in colon premalignant organoids from a patient with familial adenomatous polyposis (FAP), albeit to a lesser extent, likely due to strong stem cell cues from WNT/R-spondin/Noggin containing conditioned media (Supplementary Fig. 4d); similar results were achieved with KMT2A KD but not SMARCA4 KD (Supplementary Fig. 4d).