While SOX9 shows a near-preferential dependency in MSS relative to MSI CRC cell lines (t(40) = −1.814, p = 0.0772), the impact of SMARCB1 loss was similar in CRC cell lines irrespective of MSI status (t(40) = −0.656, p = 0.516) (Fig. 5a). This evidence concerns the gene SOX9 and colorectal carcinoma.