LAMB1 is a kind of extracellular matrix glycoprotein, which is mainly related to cell adhesion and migration; VNN1 is also a secreted protein mainly expressed in hepatocytes, however, it has been reported that knockout of VNN1 can promote the accumulation of TG in the liver under fasting state,16 suggesting that elevated VNN1 may not be a inducer of NAFLD. Here, VNN1 is linked to metabolic dysfunction-associated steatotic liver disease.