SERPINA4 and fatty liver disease: To further investigate the key role of CGI-58 in hepatocytes regarding hepatic steatosis and inflammation induced by KAL, we constructed hepatic-specific CGI-58-transgenic mice (CGI-58LSL/+:Cre), which were bred with KAL-Tg mice to construct the hepatic CGI-58-overexpressing KAL-Tg mouse model (KAL + CGI-58LSL/+:Cre).