We also found that the alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in HTG were higher than those in the HLP without HTG group and the healthy control group and positively correlated with KAL (Fig. 1d-e, supplementary Fig. 1f-g). The gene discussed is SERPINA4; the disease is hyperkeratosis lenticularis perstans.