Our RNAseq result of primary hepatocytes from 6-month-old WT and KAL-Tg mice indicated the downregulation of ATGL (encoded by the Pnpla2) and CGI-58 (encoded by the Abhd5) (supplementary Fig. 3a-b) (GSA dataset CRA014927), which are closed related with NAFLD. This evidence concerns the gene SERPINA4 and metabolic dysfunction-associated steatotic liver disease.