Metformin and Berberine have demonstrated a broad spectrum of pharmacological effects and potential therapeutic effects on NAFLD; Fenofibrate is a kind of drug for treating HLP, especially severe HTG, and can reduce the content of FFA while reducing TG.52 We found that Fenofibrate, but not Metformin and Berberine, down-regulates KAL levels. The gene discussed is SERPINA4; the disease is metabolic dysfunction-associated steatotic liver disease.