An example highlighting the effectiveness of Salmonella-based bacterial delivery of constitutively active caspase-3 blocked the development of hepatocellular carcinoma and lung metastases.131 Moreover, the optimized attenuated Salmonella Typhimurium was utilized as a live vector to deliver antitumor molecules, including the angiogenesis inhibitor endostatin and apoptosis inducer TRAIL, and subsequent studies confirmed that the colonization of Salmonella bacteria in tumor tissue led to significant cell apoptosis and tumor angiogenesis suppression.132. This evidence concerns the gene CASP3 and neoplasm.