In view of these published articles along with our data, we hypothesized that hypoxia might alter the exosomal Circ-ZNF609 expression from ESCC cells and sponges miR-150-5p which triggered VEGFA dysregulation and alter right junction protein expression by interacting with HuR in host cells-HUVECs. Here, VEGFA is linked to esophageal squamous cell carcinoma.