[22, 43] Here, we showed that exosomal-Circ-ZNF609 from ESCC effectively disrupts of blood vessel barrier and weakened the adherent junction molecules at least partially by preventing HuR association with Claudin-1, Occludin and ZO-1 mRNAs, thereby inhibiting their expression in brain, lung and liver. This evidence concerns the gene ZNF609 and esophageal squamous cell carcinoma.