For example, pyogenic spondylodiscitis is able to cause severe osteolytic and destructive lesions37, while osteomyelitis and osteoporosis can both lead to loss of bone mass, where infections can alter RANKL-RANK-OPG signaling that is involved in the regulation of osteoblast and osteoclast behavior38. This evidence concerns the gene TNFRSF11A and osteomyelitis.