For example, compared to the normal and osteopenia groups, Klebsiella quasipneumoniae and Veillonella parvula had specific expression in osteoporosis CIS1, and 3-hydroxybutyric acid tended to be upregulated in osteoporosis CIS1, while, in contrast, threonic acid was upregulated in osteoporosis CIS2 (Fig. 4e). The gene discussed is SOCS2; the disease is Osteopenia.