IL6 and acute respiratory distress syndrome: IL-6, IL-8, sTNFr1 and vasopressor use were available from our septic shock datasets, allowing us to fit two of the parsimonious ARDS models.42 The ARDS models classified the majority of patients as hyperinflamed (model 1 (IL-8, sTNFr1, vasopressors) 84% overall, 72% VANISH and 88% LeoPARDS; model 2 (IL-6, sTNFr1, vasopressors) 84% overall, 80% VANISH and 86% LeoPARDS) and showed limited concordance with our models (online supplemental table S11).