MMP8 and acute respiratory distress syndrome: Several of the genes that we found differentially expressed between our two cytokine groups were previously found to be differentially expressed between patients allocated to ARDS ‘reactive’ and ‘uninflamed’ biologic phenotypes.45 Of particular note are the MMP8 and MME genes which showed the greatest fold changes between phenotypes in both sets of analysis with MMP8 being overexpressed by the high inflammatory and MME by the low inflammatory phenotypes in both studies.