According to The Cancer Genome Atlas (TCGA) data, melanoma can be genomically subdivided into the following 4 groups based on the mutated genes; mutant BRAF, mutant RAS, mutant NF1, and triple-wild type (Triple-WT) groups.13 Conventionally, BRAF mutation was assessed via polymerase chain reaction (PCR)—based assay, but with the advent of expert gene panels, next-generation sequencing (NGS) has emerged as a more accessible and high-throughput method. This evidence concerns the gene BRAF and melanoma.