There is not much information on the relationship of MMPs with diet, nor a very comprehensive understanding of the relationship between them and obesity; however, it is known that adipocytes play an important role in the production and release of MMP-2 and MMP-9 in individuals with obesity and that they are elevated in these individuals [28,31]. The gene discussed is MMP2; the disease is obesity due to melanocortin 4 receptor deficiency.