In addition, levels of active phosphorylated IKK2 (p-IKK2) and p65 (p-p65) as well as inflammatory markers (Il1b, Il6, Tnfa, and iNOS) were higher in the aortic media of CKD mice (Figure 1, C and D, and Supplemental Figure 1G). This evidence concerns the gene IL1B and chronic kidney disease.