In addition, levels of active phosphorylated IKK2 (p-IKK2) and p65 (p-p65) as well as inflammatory markers (Il1b, Il6, Tnfa, and iNOS) were higher in the aortic media of CKD mice (Figure 1, C and D, and Supplemental Figure 1G). The gene discussed is TNF; the disease is chronic kidney disease.