IL-17C is expressed primarily by epithelial cells, including KCs, and binds to IL-17RE and IL-17RA (5, 6) to promote and amplify innate defense in epithelial cells; despite repeated implications for its role in the pathogenesis of inflammatory skin disorders, including psoriasis (Ps) and atopic dermatitis (AD) (7), its transcriptional regulation is not well understood. The gene discussed is IL17C; the disease is psoriasis.