To better understand the effect of IL-17C in KCs, we generated KOs of each IL-17 receptor subunit (IL17RA, IL17RE, IL17RC KOs) using CRISPR/Cas9 approaches (26) and performed RNA-Seq with and without 8 hours of cytokine stimulation (IL-17C, TNF-α + IL-17C, IL-17A, and TNF-α + IL-17A). The gene discussed is IL17C; the disease is dry eye syndrome.