IL17C and inflammatory skin disease: IL-17C is expressed primarily by epithelial cells, including KCs, and binds to IL-17RE and IL-17RA (5, 6) to promote and amplify innate defense in epithelial cells; despite repeated implications for its role in the pathogenesis of inflammatory skin disorders, including psoriasis (Ps) and atopic dermatitis (AD) (7), its transcriptional regulation is not well understood.