Here we report that TCF4 negatively regulates IL-17C and ZC3H12A (also known as, MCPIP1/Regnase-1) expression in human KCs and that IL-17C further promotes the expression of ZC3H12A and NFKBIZ in an IL-17RA/RE–dependent manner. The gene discussed is IL17RA; the disease is dry eye syndrome.