Our findings that TCF4 negatively regulates inflammation in KCs support findings by others who have shown that loss of Tcf4 in DCs leads to increases in DC-derived IL-6, IL-23, IL-1β, TNF-β, and IL-12p40, which in turn lead to increases in T cell–derived IL-17A and IFN-γ and exacerbate experimental autoimmune encephalitis (EAE) (50). Here, TCF4 is linked to dry eye syndrome.