ITGB5 and hepatocellular carcinoma: Additionally, overexpression of the β5 integrin promotes HCC cell migration and carcinogenesis both in vitro and in vivo.43 Furthermore, upregulation of αVβ5 induced HCC proliferation and drove HCC angiogenesis.20 From our meta-analysis result, we demonstrated that the gene expression of ITGAV and ITGB5, analysed from obtained samples in GEO, was significantly upregulated in HCC tissues compared with normal liver tissue.