Both teams and our research partners have demonstrated its effectiveness in a variety of pre-clinical human cancer models, including melanoma, breast, prostate, brain, and pancreatic cancer, and chondrosarcoma.15,54–59 Next, we plan to further investigate the efficacy and safety of this tumour-targeted TPA-tmTRAIL particles in the animal model of hepatocarcinoma. The gene discussed is PLAT; the disease is familial pancreatic carcinoma.