DR4 and DR5 can also be expressed in cells within the tumour microenvironment, such as stromal cells and endothelial cells.49 In contrast, DR4 and DR5 are typically expressed at low levels in normal cells.1,2 Our findings showed that Huh-7 and HepG2 overexpress DR5 receptors. The gene discussed is TNFRSF10B; the disease is neoplasm.