We recently reported on thedevelopment of a cell-based assay monitoringKyn levels after stimulation of BxPC-3 cells with the cytokine interferon-γ(IFN-γ) to induce expression of IDO1.34 Using this assay, we have now identified N-substitutedindoles as a compound class that potently reduce cellular Kyn levelsupon stimulation of cancer cells with IFN-γ.34,35 These small molecules do not inhibit IDO1 activity or expression,but modulate the Kyn pathway by targeting soluble epoxide hydrolase(sEH). This evidence concerns the gene EPHX2 and cancer.