In addition, central disturbances were reported, such as (signs of) hypogonadotropic hypogonadism including micropenis, undescended testis, primary amenorrhea, or delayed puberty in 16 of 103 patients [16%; including in all 12 adult patients (100%)], central hypothyroidism (n = 1), 1 suspected case of growth hormone deficiency, and 3 reports on insufficient growth hormone secretion despite normal growth in 3 patients. Here, GH1 is linked to hypogonadotropic hypogonadism.