Notably, among all upregulated glycopeptides, the top three were derived from LAMP1 on a single glycosylation site (Asn249), on which monosaccharide HexNAc was increased approximately 200-fold, xeno-tetrasaccharide (NeuAc-Gal-GlcNAc2) more than 150-fold and chitobiose (HexNAc2) about 100-fold in ALG1-CDG patients. This evidence concerns the gene LAMP1 and congenital disorder of glycosylation.